What is the (p-) value of the P-value?

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P-value: What is and what is not

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Consider an experiment in which 10 subjects receive a placebo, and another 10 receive an experimental diuretic. After 8 h, the average urine output in the placebo group is 769 mL, versus 814 mL in the diuretic group—a difference of 45 mL (Figure 1). How do we know if that difference means the drug works and is not just a result of chance? of 45 mL in the average urine output between groups unde...

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Researchers aim to make the strongest possible conclusions from limited amounts of data. To do this, they need to overcome two problems. First, important differences in the fi ndings can be obscured by natural variability and experimental imprecision. Thus, it is diffi cult to distinguish real differences from random variability. Second, researchers’ natural inclination is to conclude that diff...

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ژورنال

عنوان ژورنال: Leukemia

سال: 2016

ISSN: 0887-6924,1476-5551

DOI: 10.1038/leu.2016.193